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Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein Free
Yingjie Xu1, Wen Yang2, Jinjun Shi3, and Bruce R. Zetter1,*
1Vascular Biology Program, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA
2Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA
3Laboratory for Nanoengineering and Drug Delivery, Department of Anesthesiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA *Correspondence to:Bruce R. Zetter, E-mail: bruce.zetter@childrens.harvard.edu
J Mol Cell Biol, Volume 8, Issue 3, June 2016, 282-285,  https://doi.org/10.1093/jmcb/mjw018

Dear Editor,

Prohibitin 1 (PHB1) was identified previously as a protein that is upregulated and translocated to the plasma membrane in taxane-resistant cancer cells. We found that PHB1 silencing re-sensitized taxane-resistant cancer cells to apoptosis and to paclitaxel treatment both in vitro and in vivo (Patel et al., 2010). In line with our findings, overexpression of PHB1 has been shown to markedly attenuate ceramide-, staurosporine (STS)-, camptothecin-, or serum withdrawal-induced apoptosis via the intrinsic apoptotic pathway (Peng et al., 2015).


Volume 8, Issue 3
June 2016